Biomarkers in Arthroplasty: A Systematic Review
نویسندگان
چکیده
We performed a systematic review of all MEDLINE-published studies of biomarkers in arthroplasty. Thirty studies met the inclusion criteria; majority evaluated biomarkers for osteolysis, aseptic prosthetic loosening, and prosthetic infections. Four studies reported an elevated Cross-linked N-telopeptides of type I collagen (urine or serum) in patients with osteolysis or aseptic prosthetic loosening when compared to appropriate controls. Two or more studies each found elevated C-reactive protein, erythrocyte sedimentation rate, and interleukin-6 in patients with infected prosthetic joints compared to controls. Most other biomarkers were either examined by single studies or had inconsistent or insignificant associations with outcomes. We conclude that the majority of the biomarkers currently lack the evidence to be considered as biomarkers for arthroplasty outcomes. Further studies are needed.
منابع مشابه
Effect of Fructose Intake on Metabolic Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review of Randomized Clinical Trial Studies
Introduction: Fructose is a lipogenic monosaccharide affecting glucose homeostasis and other metabolic biomarkers; however, there is conflicting evidence in this regard. The current systematic review aimed to determine the effects of fructose on metabolic biomarkers in individuals with T2DM using randomized clinical trial studies. Materials and Methods: In this systematic review study, after se...
متن کاملAcromial Stress Fractures: A Systematic Review
Background: Acromial stress fracture (ASF) is a unique complication of reverse shoulder arthroplasty (RSA) thatcan have substantial influence on clinical results. The purpose of this review is to describe demographics, functionaloutcomes, and union rates for cases of RSA complicated by ASF.Methods: A systematic review was conducted using Preferred Reporting Items for Systemati...
متن کاملUnicompartmental Knee Osteoarthritis (UKOA): Unicompartmental Knee Arthroplasty (UKA) or High Tibial Osteotomy (HTO)?
Background: The aim of this review article is to analyze the results of high tibial osteotomy compared to unicompartmental knee arthroplasty in patients with unicompartmental knee osteoarthritis. Methods: The search engine used was PubMed. The keywords were: "high tibial osteotomy versus unicompartmental knee arthroplasty". Twenty-one articles were found on 28 February 2015, but only eighte...
متن کاملDoes a Previous High Tibial Osteotomy (HTO) Influence the Long-term Function or Survival of a Total Knee Arthroplasty (TKA)?
High tibial osteotomy (HTO) is a well established technique for the treatment of medial osteoarthritis ofthe knee with varus malalignment. The outcome of total knee arthroplasty (TKA) after HTO remains uncertain.The aim of this paper is to revise the literature with the aim of answering the following question: Does a previous (HTO)influence the long-term function or survival of a TKA?. The sea...
متن کاملDiagnostic Biomarkers of Heat Stress Induced- DNA in Occupational Exposure: A Systematic Review
Introduction: Climate change and hot processes in the workplaces has led to an increase in the effects of heat stress on employed people, which has become a major concern, especially in tropical and subtropical countries. Early detection of biomarkers in induction of heat stress-related DNA damage can be used in the identification and evaluation of health and safety, including occupational heal...
متن کامل